研究内容

8. 研究論文リスト

(56)W. Nomura, T. Narumi, N. Ohashi, Y. Serizawa, N. E. Lewin, P. M. Blumberg, T. Furuta, H. Tamamura, Synthetic Caged DAG-lactones for Photochemically Controlled Activation of Protein Kinase C, ChemBioChem, 12, 535–539 (2011)

(55)S. Mizukami, M. Hosoda, T. Satake, S. Okada, Y. Hori, T. Furuta and K. Kikuchi, Photocontrolled Compound Release System Using Caged Antimicrobial Peptide, J. Am. Chem. Soc. 132, 9524-9525 (2010)

(54)A. Shigenaga, J. Yamamoto, Y. Sumikawa, T. Furuta, A. Otaka, Development and photo-sensitive peptide bond cleavage reaction of two-photon near infrared excitation-responsive peptide, Tetrahedron Lett. 51, 2868-2871 (2010)

(53)Yamaguchi, S., Chen, Y., Nakajima, S., Furuta, T., Nagamune, T. Light-activated gene expression from site-specific caged DNA with a biotinylated photolabile protection group, Chem. Commun. 46, 2244-2246 (2010)

(52)Hishikawa, K., Nakagawa, H., Furuta, T., Fukuhara, K., Tsumoto, H., Suzuki, T., Miyata, N. Multiple bond-conjugated photoinduced nitric oxide releaser working with two-photon excitation. Bioorg. Med. Chem. Lett. 20, 302-305 (2010)

(51)H. Tsutsui, H. Shimizu, H. Mizuno, N. Nukina, T. Furuta and A. Miyawaki, The E1 mechanism in photo-induced β-elimination reactions for green-to-red conversion of fluorescent proteins, Chem. & Biol. 16, 1140-1147 (2009)

(50) K. Hishikawa, H. Nakagawa, T. Furuta, K. Fukuhara, H. Tsumoto, T. Suzuki, N. Miyata, Photoinduced nitric oxide release from a hindered nitrobenzene derivative by two-photon excitation., J. Am. Chem. Soc. 131, 7488-7489 (2009).

(49) E. J. Quann, E. Merino, T. Furuta, and M Huse, Localized diacylglycerol drives the polarization of the microtubule-organizing center in T cells,Nature Immun. 10, 627-635 (2009).

(48) K. Katayama, S. Tsukiji, T. Furuta, and T. Nagamune, A bromocoumarin-based linker for synthesis of photocleavable peptidoconjugates with high photosensitivity. Chem Commun, 5399-5401 (2008).

(47) T. Kawakami, H. Cheng, S. Hashiro, Y. Nomura, S. Tsukiji, T. Furuta, T. Nagamune, A Caged Phosphopeptide-Based Approach for Photochemical Activation of Kinases in Living Cells, ChemBioChem, 9, 1583-1586 (2008).

(46) C. Orang, A. Specht, D. Puliti, E. Sakr, T. Furuta, B. Winsor, M. Goeldner, Synthesis and Photochemical Properties of a Light-activated Fluorophore to label His-tagged Proteins, Chem. Commun. 1217-1219 (2008)

(45) T. Furuta, S. Tanabe, T. Watanabe, J. Sakyo, C. Matsuba, Phototriggers for Nucleobases with Improved Photochemicasl Properties Org. Lett. 9, 4717-4720 (2007)

(44) I. Hayashi, H. Mizuno, K. I. Tong, T. Furuta, F. Tanaka, M. Yoshimura, A. Miyawaki, M. Ikura, Crystallographic Evidence for Water-assisted Photo-induced Peptide Cleavage in the Stony Coral Fluorescent Protein Kaede, J. Mol. Biol., 372, 918-926 (2007)[Citing References]

(43) A. Specht, J. S. Thomann, K. Alarcon, W. Wittayanan, D. Ogden, T. Furuta, Y. Kurakawa, M. Goeldner, New Photoremovable Protecting Groups for Carboxylic Acids with High Photolytic Efficiencies at Near-UV Irradiation. Application to the Photocontrolled Release of L-Glutamate. ChemBioChem. 7, 1690-1695 (2006)[Citing References]

(42) H. Ando, M. Kobayashi, T. Tsubokawa, K. Uyemura, T. Furuta, H. Okamoto, Lhx2 mediates the activity of Six3 in zebrafish forebrain growth. Dev Biol; 287, 456-468 (2005)[Citing References]

(41) C. D. Wood, T. Nishigaki, T. Furuta, S. A. Baba, A. Darszon, Real-time analysis of the role of Ca2+ in flagellar movement and motility in single sea urchin sperm, J. Cell. Biol. 169, 725-731 (2005)[Citing References]

(40) T. Furuta, K. Noguchi, Controlling cellular systems with Bhc-caged compounds, Trends Anal. Chem. 23, 511-519 (2004) [Citing References]

(39) T. Furuta, H. Takeuchi, M. Isozaki, Y. Takahashi, M. Sugimoto, M. Kanehara, T. Watanabe, K. Noguchi, T. M. Dore, T. Kurahashi, M. Iwamura, R. Y. Tsien, Bhc-cNMPs as either water-soluble or membrane-permeant photo-releasable cyclic nucleotides for both one and two-photon excitation, ChemBioChem, 5, 1119-1128 (2004)[PubMed] [Citing References]

(38) H. Ando, T. Furuta, H. Okamoto, Photo-mediated Gene Activation using Caged mRNA in Zebrafish Embryos, Methods in Cell Biology 77, 159-171 (2004)

(37) T. Nishigaki, C. D. Wood, Y. Tatsu, N. Yumoto, T. Furuta, D. Ellias, K. Shiba, S. A. Baba, A. Darszon, A sea urchin jelly peptide induces a cGMP-mediated decrease in sperm intracellular Ca2+ before its increase, Dev. Biol. 272, 376-388 (2004) [PubMed] [Citing References]

(36) T. Furuta, K. Nishiyama, A. Manabe, M. Fukuoka, M. Iwamura, Design, synthesis and photochemical properties of caged compounds of lipid mediators, Proceedings of the ISBC 2003, 124-125 (2003).

(35) A. Z. Suzuki, T. Watanabe, M. Kawamoto, K. Nishiyama, H. Yamashita, M. Iwamura and T. Furuta, Coumarin-4-ylmethoxycarbonyls as Phototriggers for Alcohols and Phenols, Org. Lett., 5, 4867-4870 (2003) [PubMed] [Citing References]

(34) H. Mizuno, T. K. Mal, K. I. Tong, R. Ando, T. Furuta, M. Ikura, A. Miyawaki, Photo-induced peptide cleavage for the green-to-red conversion of a fluorescent protein, Molecular Cell 12, 1051-1058 (2003) [PubMed]

(33) Y. Hirayama, M. Iwamura and T. Furuta, Design, Synthesis and Photochemical Properties of Caged Bile Acids, Bioorg. Med. Chem. Lett., 13, 905-908 (2003) [PubMed] [Citing References]

(32) H. Mizuta, S. Watanabe, H. Sakauchi, K. Nishiyama, T. Furuta, Y. Kobayashi and M. Iwamura, Design, Synthesis, photochemical properties and cytotoxic activities of water-soluble caged leucyl-leucine methyl esters that control apoptosis of immune cells. Bioorg. Med. Chem, 10 (3), 675-683 (2002) [PubMed]

(31) T. Furuta, Y. Hirayama and M. Iwamura, Anthraquinone-2-ylmethoxycarbonyl (Aqmoc): a new photochemically removable protecting group for alcohols. Org. Lett. 3, 1809-1812 (2001) [PubMed] [Citing References]

(30) H. Ando, T. Furuta, R. Y. Tsien and H. Okamoto, Photo-mediated gene activation using caged RNA/DNA in zebrafish embryos. Nature Genetics, 28, 317-325 (2001) [PubMed] [Citing References]

(29) T. Furuta, S. S.-H. Wang, J. L. Dantzker, T. M. Dore, W. J. Bybee, E. M. Callaway, W. Denk and R. Y. Tsien, Brominated 7-Hydroxycoumarin-4-ylmethyls: Photolabile Protecting Groups with Biologically Useful Cross-sections for Two Photon Photolysis, Proc. Natl. Acad. Sci. USA, 96, 1193-1200 (1999) [PubMed] [Citing References]

(28) J. Kawakami, T.Furuta, J. Nakamura, A. Uchida and M. Iwamura, Correlation of Exciplex Formation with Ground State Conformation in Flexible Bichromophoric Esters: 2-(1-Pyrenyl)ethyl p-Cyanobenzoate and Its Model Compounds, Bull. Chem. Soc. Jpn., 72, 47-54 (1999)

(27) T. Furuta and M. Iwamura, New Caged Groups: 7-Substituted coumarinylmethyl Phosphate Esters, Methods in Enzymology, 291, 50-63 (1998) [PubMed] [Citing References]

(26) H. Sakauchi, T. Furuta, Y. Kobayashi and M Iwamura, Synthesis and Cytotoxic Studies of 5-O-(b-Glucopyranosyl)-2-nitrobenzyl Caged L-Leucyl-L-Leucine Methyl Ester with Increased Solubility in PBS Containing 1% DMSO, Biochem. Biophys. Res. Commun. 233, 211-215, (1997) [PubMed]

(25) T. Furuta, A. Momotake, M. Sugimoto, M. Hatayama, H. Torigai and M. Iwamura, Acyloxycoumarinylmethyl-Caged cAMP, the Photolabile and Membrane-ermeable Derivative of cAMP That Effectively Stimulates Pigment-Dispersion Response of Melanophores, Biochem. Biophys. Res. Commun. 228, 193-198, (1996) [PubMed] [Citing References]

(24) T. Uyehara, T. Inayama, T. Furuta, T. Kato, Y. Yamamoto, M. Ueno and T. Sato, Bull. Chem. Soc. Jpn. 69, 1727-1735, (1996)

(23) M. Odaka, T. Furuta, Y. Kobayashi and M. Iwamura, Synthesis, Photoreactivity and Cytotoxic Activity of Caged Compounds of L-Leucyl-L-Leucine Methyl Ester, an Apoptosis Inducer, Photochemistry and Photobiology, 63, 800-806, (1996) [PubMed]

(22) T. Furuta, K. Takeuchi and M. Iwamura, Activation of Selenoglycoside by Photoinduced Electron Transfer. Chem. Commun. 157-158, (1996) [Citing References]

(21) M. Odaka, T. Furuta, Y. Kobayashi and M. Iwamura, Synthesis of Caged Compounds of L-leucyl-L-leucine Methyl Ester, an Apoptosis Inducer, and Their Cytotoxic Activity. Biochem. Biophys. Res. Commun. 213, 652-656, (1995) [PubMed]

(20) T. Furuta, H. Torigai, M. Sugimoto and M. Iwamura, Photochemical Properties of New Photolabile cAMP Derivatives in a Physiological Saline Solution. J. Org. Chem. 60, 3953-3956, (1995) [Citing References]

(19) S. Okada, S. Yamashita, T. Furuta, and M. Iwamura, (1-Pyrenyl)methyl Carbamates for Fluorescent “Caged” Amino Acids and Peptides. Photochemistry and Photobiology, 61, 431-434, (1995) [PubMed] [Citing References]

(18) T. Furuta and M. Iwamura, Stereodivergent Synthesis of Two Diastereoisomeric Enoates by Asymmetric Horner-Wadsworth Emmons Reaction using a Single Chiral Auxiliary. J. Chem. Soc., Chem. Commun. 2167-2168, (1994) [Citing References]

(17) T. Furuta, H. Torigai, T. Osawa, and M. Iwamura, Direct Esterification of Phosphates with Various Halides and its Application to Synthesis of cAMP Alkyl Triesters. J. Chem. Soc., Perkin Trans. 1, 3139-3142, (1993) [Citing References]

(16) T. Furuta, H. Torigai, T. Osawa, and M. Iwamura, New Photochemically Labile Protecting Group for Phosphates. Chem. Lett. 1179-1182, (1993) [Citing References]

(15) I. Suzuki, T. Furuta, and Y. Yamamoto, Synthesis of a-alkoxyalkyltributyllead compounds via the reaction of tributylplumbyllithium with a-chloroethers, and the conjugate addition of tributylplumbyllithium to enones. J. Organomet. Chem. 443, C6-C7, (1993)

(14) T. Furuta, J. Matsuo, T. Kurata, and Y. Yamamoto, Cleavage of Esters under Nearly Neutral Conditions at High Pressure. High Pressure Research, 11, 93-106, (1992)

(13) T. Furuta, E. Oshima, and Y. Yamamoto, A New Method for Construction of Cyclic Enones via Phosphonate Anions. Heteroatom Chem. 3, 471-478, (1992)

(12) T. Furuta, and Y. Yamamoto, Very High Diastereofacial Stereoselectivity in the a-Methoxy Organolead-Aldehyde Condensation. Stereocontrol of Three Contiguous Chiral Centres. J. Chem. Soc., Chem. Commun. 863-864, (1992)

(11) T. Furuta, and Y. Yamamoto, Stereocontrol of Three Contiguous Chiral Centers of Brassinosteroid Side Chain Using a-Alkoxy Organoleads. J. Org. Chem. 57, 2981-2982, (1992)

(10) Y. Yamamoto, T. Furuta, J. Matsuo, and T. Kurata, Cleavage of Esters under Nearly Neutral Conditions at High Pressure. Chemo- and Regioselective Hydrolysis in Organic Solvents. J. Org. Chem. 56, 5737-5738, (1991)

(9) Y. Yamamoto, and T. Furuta, A Multistep Rearrangement from 2,2-Disubstituted 1,3-Cyclohexane-diones to 3-Substituted 2-Cyclohexenones via Phosphonate Anions and Its Application to a Formal Synthesis of (±)-a-acoradiene. J. Org. Chem. 55, 3971-3972, (1990)

(8) T. Uyehara, T. Furuta, M. Akamatsu, T. Kato, and Y. Yamamoto, Construction of Fused-Ring Skeletons Based on Photochemical Rearrangements of Bicyclo[3.2.1]oct-6-en-2-ones and Application to a Total Synthesis of (±)-D9,12 Capnellene. J. Org. Chem. 54, 5411-5413, (1989)

(7) Y. Yamamoto, and T. Furuta, Triethylgallium Mediated Lactamization of a,w-Amino Carboxylic Acids. Chem. Lett. 797-800, (1989)

(6) T. Uyehara, T. Furuta, Y. Kabasawa, J. Yamada, T. Kato, and Y. Yamamoto, Rearrangement Approaches to Cyclic Skeletons 6. Total Synthesis of (±)-Ptilocaulin on the Basis of Formal Bridgehead Substitution and Photochemical [1,3] Acyl Migration of a Bicyclo[3.2.2]non-6-en-2-one System. J. Org. Chem. 53, 3669-3673, (1988)

(5) T. Uyehara, J. Yamada, T. Furuta, T. Kato, and Y. Yamamoto, Rearrangement Approaches to Cyclic Skeletons.5. Formal Bridgehead Substitution of 1-Methoxybicyclo[3.2.2]non-6-en-2-ones and its Application to a Total Synthesis of (±)-Widdrol. Tetrahedron, 43, 5605-5620, (1987)

(4) T. Uyehara, J. Yamada, T. Furuta, and T. Kato, A Total Synthesis of (±)-Widdrol. Synthetic Application of the Formal Bridgehead Substitution of 1-Methoxybicyclo[3.2.2]non-6-en-2-ones with Alkyl Groups. Chem. Lett. 609-612, (1986)

(3) T. Uyehara, T. Furuta, Y. Kabasawa, J. Yamada, and T. Kato, Total Synthesis of (±)-Ptilocaulin Starting from Tropolone. J. Chem. Soc., Chem. Commun. 539-540, (1986)

(2) T. Uyehara, Y. Kabasawa, T. Furuta, and T. Kato, Rearrangement Approaches to Cyclic Skeletons.3. Practical Route to cis-Bicyclo[4.3.0]non-4-en-7-ones Based on Photochemical [1,3] Acyl Migration of Bicyclo[3.2.2]non-6-en-2-ones. Bull. Chem. Soc. Jpn., 59, 539-543, (1986)

(1) T. Uyehara, Y. Kabasawa, T. Kato, and T. Furuta, Photochemical Rearrangement Approach to the Total Synthesis of (±)- Pinguisone and (±)-Deoxopinguisone. Tetrahedron Lett., 2343-2346, (1985)

研究総説,解説等リスト

(1) 古田寿昭,自己組織化した分子における光誘起電子移動,化学と工業,12,2236-2237,1991

(2) 古田寿昭,2光子励起レーザー走査顕微鏡,生化学,73,1308,2001

(3) 安藤秀樹,古田寿昭,岡本 仁,光で遺伝子発現を操る方法の開発,蛋白質 核酸 酵素,47,125-13,2002

(4) 安藤秀樹,古田寿昭,岡本 仁,光量子によるゼブラフィッシュ胚での標的遺伝子の時空間特異的強制発現,細胞工学,21,217-221,2002

(5) 古田寿昭,光で生理活性をオンオフできるスイッチ,現代化学,24-31,2002

(6) 古田寿昭,光で働くスイッチ−生き物の情報の流れを光で制御する,生命化学研究レター,11, 12-16, 2003.

(7) 安藤秀樹,古田寿昭,岡本 仁,新規ケージド化合物を用いた遺伝子の光によるスイッチオン/オフ技術,生化学,75,1251-1254,2003

(8) 古田寿昭,ケージド化合物,生化学,76, 2004

(9) 古田寿昭,光であやつる細胞機能,光学,34 (4) 213-219, 2005

(10) 古田寿昭,タンパク質の機能を光で制御する,ファルマシア,41 (8) 789-790, 2005

(11) 古田寿昭,細胞のリモートコントロール,ファルマシア,42, 446-450 (2006)

(12) 古田寿昭,光で細胞機能をあやつるケージド化合物,バイオインダストリー,23, 58-64 (2006)

(13) 古田寿昭,生理機能を光制御するケージド化合物―Problem Oriented Researchを目指そう―,Peptide Newsletter Japan, 2-4 (2007)

(14) 古田寿昭,生理機能を制御するケージド化合物,「光機能性高分子材料の新たな潮流―最新技術とその展望―」市村國宏監修,シーエムシー出版,pp. 74-84 (2008)

(15) 古田寿昭,遺伝子の機能発現を光制御するケージド化合物,光化学,42, 2-8 (2011)

(16) 古田寿昭,鈴木商信,過渡的複合体の解析を可能にするケージド化合物,生化学,83, 966-974 (2011)

著書

(1) 古田寿昭(分担),山本嘉則(代表),第4版実験化学講座25有機合成VII,丸善,(1991年9月)

(2) 古田寿昭(分担),ケージド化合物,先端の分析法「理工学からナノ・バイオまで」エヌ・ティー・エス,pp 332-339 (2004年12月)

(3) T. Furuta, Coumarin-4-ylmethyl Phototriggers, in Dynamic Studies in Biology: Phototriggers, Photoswitches and Caged Biomolecules, M. Goeldner and R. S. Givens Eds pp29-55 in press.

(4) 西垣卓也,古田寿昭(分担),ケージド化合物による細胞応答の観察,「実験医学別冊 染色・バイオイメージング実験ハンドブック」高田邦昭,斎藤尚亮,川上速人編集,羊土社,pp. 228-236(2006年7月1日)

(5) 古田寿昭(分担),生理機能を光で制御して「見る」ケージド化合物,「別冊化学 分子イメージング」化学同人編集部編,化学同人,pp. 31-36 (2007)

(6) 古田寿昭,多機能ケージド化合物の開発,「シングルセル解析の最前線」神原秀記,松永 是,植田充美監修,シーエムシー出版,pp. 49-55, 2010, 3

(7) 古田寿昭,細胞の生理機能を光制御するCaged 化合物,化学フロンティア22 「生命現象を理解する分子ツール最前線」化学同人,2010.10

(8) 古田寿昭,遺伝子の機能発現を光制御するケージド核酸誘導体,CSJ Current Review 06 「核酸化学のニュートレンド」化学同人,2011年7月

(9) 古田寿昭,二光子励起で活性化可能なケージド化合物,「高効率二光子吸収材料の開発と応用」シーエムシー出版,2011年11月

特許

(1) R. Y. Tsien, and T. Furuta, Protecting groups with increased photosensitivities. PCT Int. Appl., WO 2000031588 (2000).

(2) 岡本仁,安藤秀樹,古田寿昭 「遺伝子発現調節方法」特願2001-124452

(3) H. Okamoto, H. Ando, T. Furuta, Method for regulating target gene expression by UV irradiation of complexes of caging agent and nucleic acid. U.S. Pat. Appl. Publ. US 2002155606 (2002).

(4) 古田寿昭,今泉奈津代,「架橋剤,架橋方法,遺伝子発現調節法及び遺伝子機能調査法」特願2005-58924,PCT/JP2006/303586

 


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